It's important to note that after completing the first Courtyard quest, subsequent runs require an Invitation to gain entry: as the Crimson Curse's Infestation grows, Bloodsuckers begin to spawn in every other location. The ability to cure it through the Sanitarium will become permanently available once the Countess is slain. The Curse is automatically removed from all heroes in your roster after slaying a Courtyard Boss. It is only found in the Crimson Court DLC.
The Crimson Curse is a persistent status effect, much like a disease (but can't be cured by camping skill Leeches and Snuff Box), that gives a hero unique conditions and may lead to the character's death if not treated. " These swarming fiends carry a pernicious plague! A sickness so virulent, so insidious, it is more a curse than a mere disease." A Hellion becoming afflicted with the Crimson Curse.
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